Irishman Walking (Stage 2 Chapter 2) -- On The Roads

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When this combines with another gamete, that has the usual complement of one chromosome 13, the result is a zygote with three copies of the chromosome. So when the parent cell is cleaved instead of there just being one chromosome 13 in a daughter gamete cell there are two. In nondisjunction the chromosome 13 pair fails to come apart during the cell division (meiosis) that leads to the formation of either an egg cell or a sperm cell. In most cases the condition is not inherited, it is usually caused by a spontaneous mutation that occurs during the formation of sperm and eggs. The type of mutation that causes Patau syndrome takes place during meiosis when either the sperm or egg cells are being created. The other type of mutation that causes Patau syndrome is a Robertsonian translocation. In theory this kind of embryo screening for genetic diseases can be used to look for any condition that is caused by a mutation in a single gene, provided that a test has been developed that can find that specific gene.

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