In some embodiments, the calcium oscillations can be a combination of two or more of AMPA-dependent, NMDA-dependent or GABA-dependent calcium oscillations. In other embodiments, the calcium oscillations can be measured as shown in Murphy et al., Gatis Sexo J. Neurosci. Spatial learning and memory can be assessed based on a Morris Water Maze test as shown in Morris J. Neurosci. In some embodiments, the behavioral score is measured by the following methods, including a novel object rejection test, a water maze test, a gait analysis test, and/or any combination thereof. NOR testing is based on the spontaneous behavior of rodents to explore a novel object more than a familiar one (Dodart et. Short term recognition memory can be measured using the novel object recognition (NOR) task. Expression produces a «gene product.» As used herein, a gene product can be either a nucleic acid, e.g., a messenger RNA produced by transcription of a gene, or a polypeptide which is translated from a transcript. Gene products described herein further include nucleic acids with post transcriptional modifications, e.g., polyadenylation or splicing, or polypeptides with post translational modifications, e.g., methylation, glycosylation, the addition of lipids, association with other protein subunits, or proteolytic cleavage. In functional assays, EC50 is the concentration of a therapeutic molecule that produces 50% of the biological response, e.g., transcription of mRNA or protein expression

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